Theoretical examination of the pulse vaccination policy in the SIR epidemic model

L. Stone, B. Shulgin, Z. Agur

Research output: Contribution to journalArticlepeer-review

Abstract

Based on a theory of population dynamics in perturbed environments, it was hypothesized that measles epidemics can be more efficiently controlled by pulse vaccination, i.e., by a vaccination effort that is pulsed over time [1]. Here, we analyze the rationale of the pulse vaccination strategy in the simple SIR epidemic model. We show that repeatedly vaccinating the susceptible population in a series of 'pulses,' it is possible to eradicate the measles infection from the entire model population. We derive the conditions for epidemic eradication under various constraints and show their dependence on the parameters of the epidemic model. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalMathematical and Computer Modelling
Volume31
Issue number4-5
DOIs
StatePublished - Feb 2000

Keywords

  • Differential equations
  • Epidemic models
  • Mathematical models
  • Pulse vaccination
  • Stability

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