Theoretical derivation of partition coefficient from solubility parameters

Shalom Srebrenik*, Sasson Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Using the free energy expansion series of Scatchard and Prentiss, we have derived an expression for the partition coefficient in terms of solubility parameters of solute and solvents, their molar volumes, and the partial molal volumes of the solute in these solvents. This treatment assumes: (1) total separation of phases; (2) absence of complexes; (3) no contribution from three-center interaction; (4) low concentration of solute; and (5) geometric mean assumption for unlike interactions.

Original languageEnglish
Pages (from-to)996-999
Number of pages4
JournalJournal of Physical Chemistry
Issue number9
StatePublished - 1976


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