The yield of the prenatal work-up in intrauterine growth restriction and the spectrum of fetal abnormalities detected postnatally

Rivka Sukenik-Halevy, Adi Katz, Rivka H. Regev, Ofer Markovitch, Reuven Sharony, Yael Ganor Paz, Tal Biron-Shental

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the yield of work-up in intrauterine growth restriction (IUGR) pregnancies and their outcomes. Materials and methods: Retrospective data regarding prenatal work-up (serology, genetic testing and imaging), and neonatal outcomes of 198 IUGR pregnancies (estimated fetal weight <10th percentile) were analyzed. Results: IUGR was isolated in 72 cases. Work-up performed in 158 (80%) cases was positive in 4 (2.5%). No abnormalities were detected in prenatal genetic testing. Echocardiogram performed in 27 cases was abnormal in 3 (11.1%). Serological testing performed in 150 pregnancies (75.8%) detected 1 case (0.7%) of cytomegalovirus (CMV) infection. Thirteen neonates (6.5%) were diagnosed with significant health problems. A positive work-up and significant postnatal health problems were not correlated with IUGR severity, symmetry or additional concurrent findings. Conclusion: The yield of IUGR work-up is not clear and is probably highest for fetal echocardiography. The rate of significant adverse outcomes after birth is increased in IUGR pregnancies.

Original languageEnglish
Pages (from-to)753-759
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume32
Issue number5
DOIs
StatePublished - 4 Mar 2019

Keywords

  • Fetal echocardiogram
  • intrauterine growth restriction
  • pregnancy outcome
  • serological testing
  • work-up

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