The wired network as a learning paradigm for normal and abnormal brain neuronal communication

The brain is a highly sophisticated assembly of neuronal networks for interaction with the internal and external environment. Fundamentally, the neuronal communication process is analogous structurally and functionally to the electrical (wire-mediated) network. In particular, both have coupled information-processing and conduction properties. We suggest that the electrical system can be used as a learning paradigm in brain research and clinical practice. Our model shows how the study of wire-mediated networks may be of benefit in tracing overt psychiatric manifestations to intrinsic biological faults in brain circuitry. (C) 2000 Harcourt Publishers Ltd.