The value of GnRH agonists in the treatment of failed cycles in an IVF-ET program: a comparative study

Dov Feldberg; Gil A. Goldman; Dov Dicker; Jacob Ashkenazi; Aryeh Yeshaya; Jack A. Goldman

doi:10.1016/0028-2243(90)90013-Q

The value of GnRH agonists in the treatment of failed cycles in an IVF-ET program: a comparative study

Dov Feldberg, Gil A. Goldman, Dov Dicker, Jacob Ashkenazi, Aryeh Yeshaya, Jack A. Goldman^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Occasionally, menotropins fail to induce ovulation for IVF-ET, due to early luteinization resulting in high cancellation rates of 15-40% of cycles. The efficacy of GnRH agonists in reducing these problems was prospectively studied in 91 women undergoing repeated IVF-ET, after desensitization with GnRH agonists. In all patients, the cycles that had been induced by menotropins alone failed due to early luteinization. By comparing these patients to a control group with significantly lower cancellation rates as well as significantly higher fertilization, the cleavage and pregnancy rates were achieved for the former group (p < 0.001 in all parameters). Pituitary down-regulation by means of GnRH agonists prior to the induction of ovulation seems to be an effective and rewarding method for minimizing cancellation rates, and for achieving improved results in IVF-ET therapy.

Original language	English
Pages (from-to)	103-109
Number of pages	7
Journal	European Journal of Obstetrics, Gynecology and Reproductive Biology
Volume	34
Issue number	1-2
DOIs	https://doi.org/10.1016/0028-2243(90)90013-Q
State	Published - 1990

Keywords

GnRH antagonist
IVF-ET program
Menstrual cycle

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10.1016/0028-2243(90)90013-Q

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title = "The value of GnRH agonists in the treatment of failed cycles in an IVF-ET program: a comparative study",

abstract = "Occasionally, menotropins fail to induce ovulation for IVF-ET, due to early luteinization resulting in high cancellation rates of 15-40% of cycles. The efficacy of GnRH agonists in reducing these problems was prospectively studied in 91 women undergoing repeated IVF-ET, after desensitization with GnRH agonists. In all patients, the cycles that had been induced by menotropins alone failed due to early luteinization. By comparing these patients to a control group with significantly lower cancellation rates as well as significantly higher fertilization, the cleavage and pregnancy rates were achieved for the former group (p < 0.001 in all parameters). Pituitary down-regulation by means of GnRH agonists prior to the induction of ovulation seems to be an effective and rewarding method for minimizing cancellation rates, and for achieving improved results in IVF-ET therapy.",

keywords = "GnRH antagonist, IVF-ET program, Menstrual cycle",

author = "Dov Feldberg and Goldman, {Gil A.} and Dov Dicker and Jacob Ashkenazi and Aryeh Yeshaya and Goldman, {Jack A.}",

year = "1990",

doi = "10.1016/0028-2243(90)90013-Q",

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T2 - a comparative study

AU - Feldberg, Dov

AU - Goldman, Gil A.

AU - Dicker, Dov

AU - Ashkenazi, Jacob

AU - Yeshaya, Aryeh

AU - Goldman, Jack A.

PY - 1990

Y1 - 1990

N2 - Occasionally, menotropins fail to induce ovulation for IVF-ET, due to early luteinization resulting in high cancellation rates of 15-40% of cycles. The efficacy of GnRH agonists in reducing these problems was prospectively studied in 91 women undergoing repeated IVF-ET, after desensitization with GnRH agonists. In all patients, the cycles that had been induced by menotropins alone failed due to early luteinization. By comparing these patients to a control group with significantly lower cancellation rates as well as significantly higher fertilization, the cleavage and pregnancy rates were achieved for the former group (p < 0.001 in all parameters). Pituitary down-regulation by means of GnRH agonists prior to the induction of ovulation seems to be an effective and rewarding method for minimizing cancellation rates, and for achieving improved results in IVF-ET therapy.

AB - Occasionally, menotropins fail to induce ovulation for IVF-ET, due to early luteinization resulting in high cancellation rates of 15-40% of cycles. The efficacy of GnRH agonists in reducing these problems was prospectively studied in 91 women undergoing repeated IVF-ET, after desensitization with GnRH agonists. In all patients, the cycles that had been induced by menotropins alone failed due to early luteinization. By comparing these patients to a control group with significantly lower cancellation rates as well as significantly higher fertilization, the cleavage and pregnancy rates were achieved for the former group (p < 0.001 in all parameters). Pituitary down-regulation by means of GnRH agonists prior to the induction of ovulation seems to be an effective and rewarding method for minimizing cancellation rates, and for achieving improved results in IVF-ET therapy.

KW - GnRH antagonist

KW - IVF-ET program

KW - Menstrual cycle

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ER -

The value of GnRH agonists in the treatment of failed cycles in an IVF-ET program: a comparative study

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Keywords

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