The value of dynamic preload variables during spontaneous ventilation

Azriel Perel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Purpose of review: To discuss the physiological significance and clinical value of dynamic preload variables in spontaneously breathing patients. Recent findings: Dynamic preload variables reflect the response of the cardiac output to a modification of preload and can therefore be used to assess fluid responsiveness. Continuous dynamic parameters that are calculated from the variations in the arterial and plethysmographic waveforms following a mechanical breath have been shown to predict fluid responsiveness much better than static preload parameters. These parameters are displayed on many patient monitors though their use is limited to mechanically ventilated patients. However, spontaneous breathing may also induce significant hemodynamic changes because of the repetitive negative swings in the pleural pressure. By better understanding the physiological basis of these changes, the same 'dynamic parameters' can be used to gain unique physiological insights during spontaneous breathing. These include the ability to identify and/or monitor respiratory rate, respiratory effort (e.g., patient-ventilator asynchrony), fluid responsiveness (to some degree), pulsus paradoxus (e.g. asthma, cardiac tamponade), and, importantly, upper airway obstruction. Summary: Although originally intended to be used only during mechanical ventilation, 'dynamic parameters' may offer valuable clinical information in spontaneously breathing patients.

Original languageEnglish
Pages (from-to)310-317
Number of pages8
JournalCurrent Opinion in Critical Care
Issue number4
StatePublished - 1 Aug 2017


  • fluid responsiveness
  • heart-lung interaction
  • plethysmographic waveform
  • pulsus paradoxus
  • upper airway obstruction


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