The utility of 68Ga-DOTATATE positron-emission tomography/computed tomography in the diagnosis, management, follow-up and prognosis of neuroendocrine tumors

Amit Tirosh, Electron Kebebew

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroendocrine tumors (NETs) are rare neoplasms that emerge mainly from the GI tract, pancreas and respiratory tract. The incidence of NETs has increased more than sixfold in the last decades. NETs typically express somatostatin receptors on their cell surface, which can be targeted by 'cold' somatostatin analogs for therapy or by 'hot' radiolabeled somatostatin analogs for tumor localization and treatment. 68-Gallium-DOTA peptides (DOTATATE, DOTATOC, DOTANOC) positron emission tomography/computed tomography is a highly accurate imaging modality for NETs that has been found to be more sensitive for NET detection than other imaging modalities. In the current review, we will discuss the clinical utility of 68-Gallium-DOTATATE positron emission tomography/computed tomography for the diagnosis and management of patients with NETs.

Original languageEnglish
Pages (from-to)111-122
Number of pages12
JournalFuture Oncology
Volume14
Issue number2
DOIs
StatePublished - Jan 2018

Keywords

  • Ga-DOTATATE
  • diagnosis
  • management
  • neuroendocrine tumors
  • PET

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