The utility of 18f-fluorodeoxyglucose positron-emission tomography/computed tomography in cutaneous b-cell lymphoma

Hana Feuerman, Igor Snast, Iris Amitay-Laish, Osnat Bairey, Aviv Barzilai, Maora Feinmesser, Daniel Mimouni, Einat Even-Sapir, Emmilia Hodak

Research output: Contribution to journalArticlepeer-review


Background: Whole-body integrated positron emission tomography / contrast-enhanced computed tomography (PET/CT) scan is increasingly used in cutaneous lymphomas. However, the value of PET/CT in the detection of cutaneous lesions in primary cutaneous B-cell lymphoma (PCBCL) has barely been investigated. Objectives: To investigate the diagnostic accuracy of PET/CT in tracking cutaneous involvement in PCBCL. Methods: A retrospective study was conducted on 35 consecutive patients diagnosed with cutaneous B-cell lymphoma according to the World Health Organization classification who were evaluated with PET/CT as the initial staging procedure before treatment. Results: Thirty-five patients met the study criteria. In two patients extracutaneous disease was detected by PET/CT and CT and confirmed by biopsy. Of the 33 patients with PCBCL, 26 (79%) had small cell PCBCL (18 marginal-zone, 8 follicle-center lymphoma) and 7 (21%) had large cell PCBCL (3 follicle-center, 3 leg-type, 1 indeterminate). PET/CT detected skin lesions in 3 of 26 patients (12%) with small-cell PCBCL as compared to 6 of 7 patients with large-cell PCBLC (86%), a 7.4-fold higher detection rate (95% confidence interval, 2.4-22, P = 0.004). The PET-positive subgroup was characterized by larger lesion size (P < 0.001) and a higher Ki-67 proliferation index (P < 0.001). Conclusions: The sensitivity of PET/CT for detecting cutaneous involvement of lymphomas is low for small-cell PCBCL but high for large-cell types, and thus may facilitate therapeutic strategies.

Original languageEnglish
Pages (from-to)580-584
Number of pages5
JournalIsrael Medical Association Journal
Issue number9
StatePublished - Sep 2019


  • B-cell lymphoma
  • Computed tomography (CT)
  • Cutaneous lymphoma
  • Positron emission tomography (PET)
  • Primary cutaneous B-cell lymphoma (PCBCL)


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