The Usefulness of the Erythrocyte Sedimentation Rate and C-reactive Protein for the Differential Diagnosis of Non-Arteritic Anterior Ischemic Optic Neuropathy in the Era of Microinflammation

Dafna Yaacobi, Einor Ben Assayag, Shlomo Berliner, Hila Saranga, Lotan Shilo, Anat Kesler

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The presence of a microinflammatory response is one of the possible pathological mechanisms related to the development of nonarteritic anterior ischemic optic neuropathy (NAAION), a common cause of optic neuropathy in old age. We tested whether individuals with NAAION harbor a heightened microinflammatory response compared to controls. Methods: We measured the erythrocyte sedimentation rate (ESR) and high sensitivity C-reactive protein (hs-CRP) in NAAION patients during hospital admission and in four matched controls for each patient, retrieved from a large cohort of 20,000 apparently healthy individuals. Results: We included 128 NAAION patients and 512 controls. No significant differences were found between patients and controls regarding the inflammatory biomarkers. Conclusions: This is the first report showing a lack of difference in ESR and hs-CRP levels between NAAION patients and matched controls, suggesting NAAION is not associated with a heightened inflammatory response, such as the one associated with multiple atherothrombotic risk factors.

Original languageEnglish
Pages (from-to)439-443
Number of pages5
JournalOcular Immunology and Inflammation
Volume30
Issue number2
DOIs
StatePublished - 2022

Keywords

  • C reactive protein
  • erythrocyte sedimentation rate
  • microinflammation
  • non-arteritic anterior ischemic optic neuropathy
  • optic neuropathy

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