The use of scopolamine in the treatment of detrusor instability

Yaron Muskat*, Ian Bukovsky, David Schneider, Rami Langer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: A prospective randomized double-blind study was done to evaluate the efficiency of transdermal scopolamine in the treatment of detrusor instability. Materials and Methods: A total of 20 female patients with detrusor instability was assigned randomly into 2 groups of 10 each. The study group received 4 transdermal scopolamine dermal patches postauricularly, while in the control group placebo patches were applied. Both groups were similar regarding patient age, parity, duration of symptoms and previous anti-incontinence surgery. Results: The patients were reassessed after 14 days. Improvement in complaints of diurnal frequency (p <0.05), nocturia (p <0.005), urgency (p <0.05) and urge incontinence (p <0.05) was noted in the study group and not in the control group. A significantly (p <0.05) less pressure increase on filling and a decreased volume at which pressure exceeded 15 cm. water (p <0.05) were noted on cystometry in the study group only. No significant side effects were reported and no patient discontinued treatment. Conclusions: Transdermal scopolamine was effective and safe in the treatment of female patients with detrusor instability.

Original languageEnglish
Pages (from-to)1989-1990
Number of pages2
JournalJournal of Urology
Volume156
Issue number6
DOIs
StatePublished - Dec 1996
Externally publishedYes

Keywords

  • administration, cutaneous
  • drug therapy
  • scopolamine
  • urinary incontinence

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