Abstract
Purpose: A prospective randomized double-blind study was done to evaluate the efficiency of transdermal scopolamine in the treatment of detrusor instability. Materials and Methods: A total of 20 female patients with detrusor instability was assigned randomly into 2 groups of 10 each. The study group received 4 transdermal scopolamine dermal patches postauricularly, while in the control group placebo patches were applied. Both groups were similar regarding patient age, parity, duration of symptoms and previous anti-incontinence surgery. Results: The patients were reassessed after 14 days. Improvement in complaints of diurnal frequency (p <0.05), nocturia (p <0.005), urgency (p <0.05) and urge incontinence (p <0.05) was noted in the study group and not in the control group. A significantly (p <0.05) less pressure increase on filling and a decreased volume at which pressure exceeded 15 cm. water (p <0.05) were noted on cystometry in the study group only. No significant side effects were reported and no patient discontinued treatment. Conclusions: Transdermal scopolamine was effective and safe in the treatment of female patients with detrusor instability.
| Original language | English |
|---|---|
| Pages (from-to) | 1989-1990 |
| Number of pages | 2 |
| Journal | Journal of Urology |
| Volume | 156 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1996 |
| Externally published | Yes |
Keywords
- administration, cutaneous
- drug therapy
- scopolamine
- urinary incontinence