The use of fibrin sealant as a glue for septoplasty and conchotomy

Objective: The aim of our study was to investigate glue properties of a fibrin sealant in cases of septoplasty and conchotomy. Design: Double-blind prospective randomized study. Materials and Methods: A study of 146 patients (80 M, 66 F) who underwent septoplasty and conchotomy was performed in Assaf Harofeh Medical Center Tzrifin, Israel. The patients were divided randomly into two groups: Group I (n=74) underwent septoplasty with transseptal suturing, and conchotomy with glue as a haemostatic. Group II (n=72) underwent septoplasty and conchotomy with glue as a haemostatic as well as septal cartilage and mucoperichodrial flaps sealant (no transseptal suturing). The glue was based on a concentrate of human clot- table proteins and purified native human thrombin. Results: Our results showed complete healing in both groups without significant differences. One late postoperative nasal bleeding occurred in group I, and none in group II. Conclusion: We conclude that the use of second-generation glue in endonasal surgery is well suited to stop nasal bleeding and seal intranasal flaps. Moreover, it might help to avoid transseptal suturing.