The Use of Brain Natriuretic Peptide as a Decision-supporting Tool in Hospitalized Patients

Regev Landau, Ana Belkin, Sapir Kon-Kfir, Nira Koren-Morag, Avishay Grupper, David Shimunov, Ben Ami Seta, Ehud Grossman, Gadi Shlomai, Avshalom Leibowitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Most dyspneic patients in internal medicine departments have co-morbidities that interfere with the clinical diagnosis. The role of brain natriuretic peptide (BNP) levels is well-established in the acute setting but not in hospitalized patients. Objectives: To evaluate the additive value of BNP tests in patients with dyspnea admitted to medical wards who did not respond to initial treatment. Methods: We searched the records of patients who were hospitalized in the department of internal medicine D at Sheba Medical Center during 2012 and were tested for BNP in the ward. Data collected included co-morbidity, medical treatments, diagnosis at presentation and discharge, lab results including BNP, re-hospitalization, and mortality at one year following hospitalization. Results: BNP results were found for 169 patients. BNP was taken 1.7 ± 2.7 days after hospitalization. According to BNP levels, dividing the patients into tertiles revealed three equally distributed groups with a distinctive character. The higher tertile was associated with higher rates of cardiac co-morbidities, including heart failure, but not chronic obstructive pulmonary disease. Higher BNP levels were related to one-year re-hospitalization and mortality. In addition, higher BNP levels were associated with higher rates of in-admission diagnosis change. Conclusions: BNP levels during hospitalization in internal medicine wards are significantly related to cardiac illness, the existence of heart failure, and patient prognosis. Thus, BNP can be a useful tool in managing dyspneic patients in this setting.

Original languageEnglish
Pages (from-to)713-718
Number of pages6
JournalIsrael Medical Association Journal
Issue number11
StatePublished - Nov 2022


  • brain natriuretic peptide (BNP)
  • diastolic dysfunction
  • dyspnea
  • heart failure
  • internal medicine


Dive into the research topics of 'The Use of Brain Natriuretic Peptide as a Decision-supporting Tool in Hospitalized Patients'. Together they form a unique fingerprint.

Cite this