The use of a chitosan-based hyaluronate gel in musculoskeletal afflictions

Dror Robinson, Shachar Pachornik, Noah Ben Shalom, Sari Sagiv, Eitan Melamed, Zvi Nevo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

INTRODUCTION: Many disorders in clinical orthopedics present tissue degeneration and lack of repair due to lack of a scaffold. Chitosan is a sugar polymer that is produced from chitin. The current abstract describes our experience with chitosan as a tissue regeneration supporting scaffold. MATERIALS AND METHODS: Several models were evaluated including the rat acute rotator cuff model, the lapine Masuda's disc degeneration model and the medial menisectomy rat model. RESULTS: The use of chitosan enhances tendon repair in the rat rotator cuff model and prevents muscle atrophy. The use of chitosan gel appears to prevent disc degeneration in the masuda model. In the osteoarthritis model the use of chitosan leads to better cartilage preservation and less osteophyte formation. Animal pain is reduced as measured using an incapacitance meter. DISCUSSION: The use of chitosan gel allows repair of several difficult animal models simulating common orthopedic maladies.

Original languageEnglish
Title of host publicationProceedings - 2nd Advanced Technologies for Enhanced Quality of Life, ATEQUAL 2010
Pages75-78
Number of pages4
DOIs
StatePublished - 2010
Event2nd Advanced Technologies for Enhanced Quality of Life, ATEQUAL 2010 - Iasi, Romania
Duration: 15 Jul 201018 Jul 2010

Publication series

NameProceedings - 2nd Advanced Technologies for Enhanced Quality of Life, ATEQUAL 2010

Conference

Conference2nd Advanced Technologies for Enhanced Quality of Life, ATEQUAL 2010
Country/TerritoryRomania
CityIasi
Period15/07/1018/07/10

Keywords

  • Acellular tissue repair
  • Chitosan
  • Mesenchymal stem cells
  • Tissue engineering

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