TY - JOUR
T1 - The uptake of rotavirus vaccine and its effectiveness in preventing acute gastroenteritis in the community
AU - Muhsen, Khitam
AU - Chodick, Gabriel
AU - Goren, Sophy
AU - Shalev, Varda
AU - Cohen, Dani
PY - 2010/12/10
Y1 - 2010/12/10
N2 - We examined the uptake of rotavirus vaccine and its effectiveness in preventing acute gastroenteritis (AGE) in the community. Data on rotavirus vaccines purchases and AGE were extracted from the computerized database of a large health maintenance organization in Israel. The incidence of AGE requiring a physician visit during 2008-09 rotavirus season among vaccinated and non-vaccinated children were compared, and vaccine effectiveness was calculated as: (1 - Relative Risk) × 100. During the study period, the uptake of rotavirus vaccine (mostly monovalent) reached 55.1% (N=19,108) of the studied cohort. The risk of AGE requiring a physician visit was 23.2% and 46.4% among vaccinated and unvaccinated children, respectively, yielding an effectiveness of 50.1% (95% CI: 47.5%, 52.6%). Rotavirus monovalent vaccine was highly effective in preventing AGE in the community.
AB - We examined the uptake of rotavirus vaccine and its effectiveness in preventing acute gastroenteritis (AGE) in the community. Data on rotavirus vaccines purchases and AGE were extracted from the computerized database of a large health maintenance organization in Israel. The incidence of AGE requiring a physician visit during 2008-09 rotavirus season among vaccinated and non-vaccinated children were compared, and vaccine effectiveness was calculated as: (1 - Relative Risk) × 100. During the study period, the uptake of rotavirus vaccine (mostly monovalent) reached 55.1% (N=19,108) of the studied cohort. The risk of AGE requiring a physician visit was 23.2% and 46.4% among vaccinated and unvaccinated children, respectively, yielding an effectiveness of 50.1% (95% CI: 47.5%, 52.6%). Rotavirus monovalent vaccine was highly effective in preventing AGE in the community.
KW - Acute gastroenteritis
KW - Effectiveness
KW - Physician visits
KW - Rotavirus vaccines
UR - http://www.scopus.com/inward/record.url?scp=78649695271&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2010.10.010
DO - 10.1016/j.vaccine.2010.10.010
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AN - SCOPUS:78649695271
SN - 0264-410X
VL - 29
SP - 91
EP - 94
JO - Vaccine
JF - Vaccine
IS - 1
ER -
