The turkey c-rap1A proto-oncogene is expressed via two distinct promoters

Ayelet Chajut, Arnona Gazit, Abraham Yaniv

Research output: Contribution to journalArticlepeer-review

Abstract

The turkey c-K-ras(B) transcript and two species of the turkey rap1A transcripts transcribed from two distinct promoters were isolated from a turkey spleen cDNA library. Turkey K-Ras and Rap1A proteins shared extensive amino acid (aa) sequence relatedness throughout their major functional domains: the four GTP-binding domains, the effector region and the C-terminal CAAX box. However, they diverged significantly in their intervening regions. In contrast, almost complete identity in the aa composition was exhibited between turkey K-Ras and Rap1A and their human homologues. The complete conservation that exists between turkey and human Rap1A, also along the polybasic C-terminal domain as opposed to Rap1B, suggests the functional relevance of these divergent residues in specifying the distinct biological functions of these two closely related proteins.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalGene
Volume177
Issue number1-2
DOIs
StatePublished - 24 Oct 1996

Keywords

  • Avian K-ras
  • cDNA

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