TY - JOUR
T1 - The turkey c-rap1A proto-oncogene is expressed via two distinct promoters
AU - Chajut, Ayelet
AU - Gazit, Arnona
AU - Yaniv, Abraham
N1 - Funding Information:
This work was supportedb y grants from the Fund for Basic Researcha, dministerebdy the Israel Academy of Sciencesa nd Humanitiest,h e Israel Cancer Research Fund, the Israel Cancer Association,a nd the Eizen Foundation-Cancer Biology ResearchC enter of Tel Aviv University.
PY - 1996/10/24
Y1 - 1996/10/24
N2 - The turkey c-K-ras(B) transcript and two species of the turkey rap1A transcripts transcribed from two distinct promoters were isolated from a turkey spleen cDNA library. Turkey K-Ras and Rap1A proteins shared extensive amino acid (aa) sequence relatedness throughout their major functional domains: the four GTP-binding domains, the effector region and the C-terminal CAAX box. However, they diverged significantly in their intervening regions. In contrast, almost complete identity in the aa composition was exhibited between turkey K-Ras and Rap1A and their human homologues. The complete conservation that exists between turkey and human Rap1A, also along the polybasic C-terminal domain as opposed to Rap1B, suggests the functional relevance of these divergent residues in specifying the distinct biological functions of these two closely related proteins.
AB - The turkey c-K-ras(B) transcript and two species of the turkey rap1A transcripts transcribed from two distinct promoters were isolated from a turkey spleen cDNA library. Turkey K-Ras and Rap1A proteins shared extensive amino acid (aa) sequence relatedness throughout their major functional domains: the four GTP-binding domains, the effector region and the C-terminal CAAX box. However, they diverged significantly in their intervening regions. In contrast, almost complete identity in the aa composition was exhibited between turkey K-Ras and Rap1A and their human homologues. The complete conservation that exists between turkey and human Rap1A, also along the polybasic C-terminal domain as opposed to Rap1B, suggests the functional relevance of these divergent residues in specifying the distinct biological functions of these two closely related proteins.
KW - Avian K-ras
KW - cDNA
UR - http://www.scopus.com/inward/record.url?scp=0030600479&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(96)00250-8
DO - 10.1016/0378-1119(96)00250-8
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AN - SCOPUS:0030600479
SN - 0378-1119
VL - 177
SP - 7
EP - 10
JO - Gene
JF - Gene
IS - 1-2
ER -