The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

Ifat Sher, Oliver C. Hanemann, Andrew P. Karplus, Anthony Bretscher*

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

Abstract

Unlike other ERM family proteins that are activated by phosphorylation, the merlin/NF2 tumor suppressor is inactivated. Sher et al. resolve this apparent contradiction by showing that the relationship between conformation and function is conserved in merlin but that the regulation of conformation-by phosphorylation and other inputs-is more complex.

Original languageEnglish
Pages (from-to)703-705
Number of pages3
JournalDevelopmental Cell
Volume22
Issue number4
DOIs
StatePublished - 17 Apr 2012
Externally publishedYes

Fingerprint

Dive into the research topics of 'The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State'. Together they form a unique fingerprint.

Cite this