The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

Ifat Sher; Oliver C. Hanemann; Andrew P. Karplus; Anthony Bretscher

doi:10.1016/j.devcel.2012.03.008

The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

Ifat Sher, Oliver C. Hanemann, Andrew P. Karplus, Anthony Bretscher^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

53 Scopus citations

Abstract

Unlike other ERM family proteins that are activated by phosphorylation, the merlin/NF2 tumor suppressor is inactivated. Sher et al. resolve this apparent contradiction by showing that the relationship between conformation and function is conserved in merlin but that the regulation of conformation-by phosphorylation and other inputs-is more complex.

Original language	English
Pages (from-to)	703-705
Number of pages	3
Journal	Developmental Cell
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2012.03.008
State	Published - 17 Apr 2012
Externally published	Yes

Funding

Funders	Funder number
National Institute of General Medical Sciences	R01GM036652

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.devcel.2012.03.008

Cite this

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abstract = "Unlike other ERM family proteins that are activated by phosphorylation, the merlin/NF2 tumor suppressor is inactivated. Sher et al. resolve this apparent contradiction by showing that the relationship between conformation and function is conserved in merlin but that the regulation of conformation-by phosphorylation and other inputs-is more complex.",

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AB - Unlike other ERM family proteins that are activated by phosphorylation, the merlin/NF2 tumor suppressor is inactivated. Sher et al. resolve this apparent contradiction by showing that the relationship between conformation and function is conserved in merlin but that the regulation of conformation-by phosphorylation and other inputs-is more complex.

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The Tumor Suppressor Merlin Controls Growth in Its Open State, and Phosphorylation Converts It to a Less-Active More-Closed State

Abstract

Funding

UN SDGs

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