TY - JOUR
T1 - The tumor microenvironment
T2 - The making of a paradigm
AU - Witz, Isaac P.
N1 - Funding Information:
The following foundations and individuals are thanked for generous grant support: The Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (Needham, MA, USA), The Ela Kodesz Institute for Research on Cancer Development and Prevention, Tel Aviv University; The Fainbarg Family Fund (Orange County, CA, USA); Bonnie and Steven Stern (New York, NY, USA), The Fred August and Adele Wolpers Charitable Fund (Clifton, NJ, USA), Natan Blutinger (West Orange, NJ, USA), Arnold and Ruth Feuerstein (Orange County, CA, USA), The Pikovsky Fund (Jerusalem, Israel); and James J. Leibman and Rita S. Leibman Endowment Fund for Cancer Research (New York, NY, USA).
PY - 2009
Y1 - 2009
N2 - What has been will be again, what has been done will be done again; there is nothing new under the sun (Ecclesiastes 1:9) Stephen Paget was the conceptual father of the role played by the Tumor Microenvironment (TME) in tumor progression. The focus of this essay is the developmental phase of the post Paget TME research. Attempts will be made to highlight some of the pioneering work of scientists from the late sixties through the eighties of last century who laid the foundations for the contemporary scientific achievements of TME research but whose ground breaking studies are rarely cited. This review should serve as a small tribute to their great work.
AB - What has been will be again, what has been done will be done again; there is nothing new under the sun (Ecclesiastes 1:9) Stephen Paget was the conceptual father of the role played by the Tumor Microenvironment (TME) in tumor progression. The focus of this essay is the developmental phase of the post Paget TME research. Attempts will be made to highlight some of the pioneering work of scientists from the late sixties through the eighties of last century who laid the foundations for the contemporary scientific achievements of TME research but whose ground breaking studies are rarely cited. This review should serve as a small tribute to their great work.
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=70350683363&partnerID=8YFLogxK
U2 - 10.1007/s12307-009-0025-8
DO - 10.1007/s12307-009-0025-8
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AN - SCOPUS:70350683363
SN - 1875-2292
VL - 2
SP - S9-S17
JO - Cancer Microenvironment
JF - Cancer Microenvironment
IS - SUPPL. 1
ER -
