The triple test markers profile among fetuses and children diagnosed with umbilical vein varix

Yaakov Melcer, Yifat Wiener, Ido Ben-Ami, Orna Levinsohn-Tavor, Noa Feldman, Ron Maymon

Research output: Contribution to journalArticlepeer-review

Abstract

Umbilical vein varix (UVV) is defined as a focal enlargement of the umbilical vein and represents approximately 4% of fetal umbilical cord malformations. The reported neonatal outcome of fetuses with UVV varies widely due to its rarity, hence the small sample sizes of the case series in the literature. Earlier studies reported high fetal mortality, but more recent reports have demonstrated no association between UVV and intrauterine fetal death. A recent study has described a possible association between UVV diagnosed prenatally and child developmental delay. The present study of fetuses with UVV was done to evaluate and compare the levels of triple test serum biomarkers used for Down syndrome screening (human chorionic gonadotropin, α-fetoprotein, and unconjugated estriol) between a group of fetuses with uneventful obstetric outcome versus a subgroup of children with developmental delay.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalJournal of Diagnostic Medical Sonography
Volume30
Issue number5
DOIs
StatePublished - 1 Sep 2014

Keywords

  • developmental delay
  • sonography
  • triple test serum biomarkers
  • umbilical vein varix

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