L'agrégation toxique des protéines : une forme de « délinquance moléculaire » activement combattue dans la cellule par les chaperones moléculaires et les protéases

Translated title of the contribution: The toxic aggregation of proteins: a kind of "molecular delinquency" actively fought in the cell by molecular chaperones and proteases

M. P. Hinault, P. Goloubinoff

Research output: Contribution to journalArticlepeer-review

Abstract

Under various stresses, mutation-sensitised proteins may spontaneously convert into inactive, aggregation-prone structures, which may be cytotoxic and infectious. In the cell, this new kind of "molecular criminality" is actively fought against by a network of molecular chaperones that can specifically identify, isolate and unfold damaged (delinquent) proteins and favour their subsequent native refolding. Irreversibly damaged molecules unable to natively refold are preferentially "executed" and recycled by proteases. Failing that, they are "imprisoned" within compact amyloids, or "evicted" from the cell. Thus, striking parallels, although of questionable ethical value, exist between protein and human criminality, and between the cellular and social responses to these different types of criminality. Fundamental differences also exist. Whereas programmed death (apoptosis) is the preferred solution chosen by aged and aggregation-stressed cells, collective suicide is seldom an option chosen by lawless human societies. More significantly, there is no clear cellular equivalent for the role of the family and the education system, which are so essential to the proper shaping of functional individuals in the society, and give rise to humanism, that favours crime prevention, reeducation and reinsertion programs over capital punishment. To the cardiologist and transplantation surgeon, the interest of molecular chaperones, in particular of Hsp70, Hsp90 and Hsp27, lays in their ability to inhibit the signalling pathway of programmed cell death. Their induction before and during ischemia, by various treatments and drugs could significantly reduce damages from the post ischemic reperfusion of organs.

Translated title of the contributionThe toxic aggregation of proteins: a kind of "molecular delinquency" actively fought in the cell by molecular chaperones and proteases
Original languageFrench
Pages (from-to)74-78
Number of pages5
JournalAnnales de Cardiologie et d'Angeiologie
Volume55
Issue number2
DOIs
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Aggresome
  • Amyloids
  • Apoptosis
  • Heat shock proteins
  • Hsp 27
  • Hsp 70
  • Hsp 90
  • Inflammation
  • Proteasome

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