The Torpedo electric organ is a model for opiate regulation of acetylcholine release

D. M. Michaelson; G. McDowall; Y. Sarne

doi:10.1016/0006-8993(84)91135-1

The Torpedo electric organ is a model for opiate regulation of acetylcholine release

D. M. Michaelson^*, G. McDowall, Y. Sarne

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Acetylcholine release from the nerve terminals of the purely cholinergic Torpedo electric organ is inhibited by morphine in a dose-dependent, naloxone-reversible fashion. In addition, it is shown that this preparation contains an enkephalin-like substance which, like acetylcholine, is present in a high concentration at the nerve terminals. These findings and the chemical homogeneity of the electric organ nerve terminals render this preparation an excellent model for the study of opiate regulation of neurotransmitter release.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	Brain Research
Volume	305
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91135-1
State	Published - 2 Jul 1984

Keywords

Torpedo
acetylcholine
electric organ
opiate receptor
opioid peptide
presynaptic receptors
synaptosomes
transmitter release

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10.1016/0006-8993(84)91135-1

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title = "The Torpedo electric organ is a model for opiate regulation of acetylcholine release",

abstract = "Acetylcholine release from the nerve terminals of the purely cholinergic Torpedo electric organ is inhibited by morphine in a dose-dependent, naloxone-reversible fashion. In addition, it is shown that this preparation contains an enkephalin-like substance which, like acetylcholine, is present in a high concentration at the nerve terminals. These findings and the chemical homogeneity of the electric organ nerve terminals render this preparation an excellent model for the study of opiate regulation of neurotransmitter release.",

keywords = "Torpedo, acetylcholine, electric organ, opiate receptor, opioid peptide, presynaptic receptors, synaptosomes, transmitter release",

author = "Michaelson, {D. M.} and G. McDowall and Y. Sarne",

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AU - McDowall, G.

AU - Sarne, Y.

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N2 - Acetylcholine release from the nerve terminals of the purely cholinergic Torpedo electric organ is inhibited by morphine in a dose-dependent, naloxone-reversible fashion. In addition, it is shown that this preparation contains an enkephalin-like substance which, like acetylcholine, is present in a high concentration at the nerve terminals. These findings and the chemical homogeneity of the electric organ nerve terminals render this preparation an excellent model for the study of opiate regulation of neurotransmitter release.

AB - Acetylcholine release from the nerve terminals of the purely cholinergic Torpedo electric organ is inhibited by morphine in a dose-dependent, naloxone-reversible fashion. In addition, it is shown that this preparation contains an enkephalin-like substance which, like acetylcholine, is present in a high concentration at the nerve terminals. These findings and the chemical homogeneity of the electric organ nerve terminals render this preparation an excellent model for the study of opiate regulation of neurotransmitter release.

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KW - electric organ

KW - opiate receptor

KW - opioid peptide

KW - presynaptic receptors

KW - synaptosomes

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The Torpedo electric organ is a model for opiate regulation of acetylcholine release

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