TY - JOUR
T1 - The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes
AU - Greenbaum, Lior
AU - Springer, Ramit Ravona
AU - Lutz, Michael W.
AU - Heymann, Anthony
AU - Lubitz, Irit
AU - Cooper, Itzik
AU - Kravitz, Efrat
AU - Sano, Mary
AU - Roses, Allen D.
AU - Silverman, Jeremy M.
AU - Saunders, Ann M.
AU - Beeri, Michal Schnaider
N1 - Funding Information:
This study was supported by the American Federation for Aging Research (Young Investigator Award 2011 to R.R.-S.), the Alzheimer׳s Association ( NIRG-11-205083 to R.R.-S.), the National Institute on Aging ( R01-AG-034087 to M.S.-B. and P50-AG-05138 to M.S.), the Helen Bader Foundation , Leroy Schecter Foundation and the Irma T. Hirschl Scholar Award (to M.S.-B.).
PY - 2014/9
Y1 - 2014/9
N2 - The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function. The short (S) allele is associated with later AD onset age and better cognitive performance, compared to the longer alleles (long and very-long (VL)). There is strong linkage disequilibrium between variants in the TOMM40 and APOE genes. In this study, we investigated the effect of '523' on cognitive performance in a sample of cognitively normal Jewish elderly with type 2 diabetes, a group at particularly high risk for cognitive impairment. Using a MANCOVA procedure, we compared homozygous carriers of the S/S allele (N=179) to carriers of the VL/VL allele (N=152), controlling for demographic and cardiovascular covariates. The S/S group performed better than the VL/VL group (p=0.048), specifically in the executive function (p=0.04) and episodic memory (p=0.050) domains. These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.
AB - The variable length poly-T, rs10524523 ('523') located within the TOMM40 gene, was recently associated with several phenotypes of cognitive function. The short (S) allele is associated with later AD onset age and better cognitive performance, compared to the longer alleles (long and very-long (VL)). There is strong linkage disequilibrium between variants in the TOMM40 and APOE genes. In this study, we investigated the effect of '523' on cognitive performance in a sample of cognitively normal Jewish elderly with type 2 diabetes, a group at particularly high risk for cognitive impairment. Using a MANCOVA procedure, we compared homozygous carriers of the S/S allele (N=179) to carriers of the VL/VL allele (N=152), controlling for demographic and cardiovascular covariates. The S/S group performed better than the VL/VL group (p=0.048), specifically in the executive function (p=0.04) and episodic memory (p=0.050) domains. These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.
KW - APOE
KW - Alzheimer's disease
KW - Cognition
KW - TOMM40
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=84907598733&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2014.06.002
DO - 10.1016/j.euroneuro.2014.06.002
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C2 - 25044051
AN - SCOPUS:84907598733
SN - 0924-977X
VL - 24
SP - 1492
EP - 1499
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 9
ER -
