The tetrazole 3-N-oxide synthesis

Tal Harel, Shlomo Rozen

Research output: Contribution to journalArticlepeer-review


An efficient procedure for transferring an oxygen atom to the 1- or 2-substituted 5-alkyl or aryl tetrazole ring, resulting, for the first time, in the corresponding N-oxides, was developed using HOF'CH3CN. This novel route features mild conditions and high yields. X-ray structure analysis and 15N NMR experiments indicate that the preferred position for the incorporation of the oxygen is on the N-3 atom.

Original languageEnglish
Pages (from-to)3141-3143
Number of pages3
JournalJournal of Organic Chemistry
Issue number9
StatePublished - 7 May 2010


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