@article{584887f6008b4ddbbf34e1bb12c21e5e,
title = "The Tat protein of the human immunodeficiency virus type 1 (HIV-1) interacts with the EGF-like repeats of the Notch proteins and the EGF precursor",
abstract = "Employing the yeast two-hybrid system, the Tat protein of the human immunodeficiency virus (HIV) was shown to interact with a region spanning the EGF-like repeats 1-6 of the mouse Notch1, the human Notch2 and the Drosophila Notch. This observation was confirmed in mammalian cells by demonstrating an interaction between the HIV Tat and the EGF-like repeats 1-6 of the various Notch proteins. The HIV Tat protein interacted also with the full-length mouse Notch1 receptor when co-expressed in mammalian cells. Moreover, the HIV Tat protein interacted also with the EGF-like repeats 1-4-spanning domain of the human EGF precursor. The ability of the HIV Tat protein to interact with the Notch proteins and possibly with other EGF-like repeats-bearing proteins, suggests that such interactions might modulate their physiological functions, thus affecting various AIDS-associated pathologies.",
keywords = "EGF-like repeats, HIV, Human immunodeficiency virus, Notch, Tat protein",
author = "Nitza Shoham and Limor Cohen and Abraham Yaniv and Arnona Gazit",
note = "Funding Information: This work was supported by a grant from the German–Israeli Foundation for Scientific Research and Development.",
year = "2003",
month = dec,
doi = "10.1016/j.virusres.2003.08.016",
language = "אנגלית",
volume = "98",
pages = "57--61",
journal = "Virus Research",
issn = "0168-1702",
publisher = "Elsevier B.V.",
number = "1",
}