The tale of early hematopoietic cell seeding in the bone marrow niche

Isaac Yaniv, Jerry Stein, Daniel L. Farkas, Nadir Askenasy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Since introduction of the notion of a "niche" that hosts engraftment and activity of hematopoietic cells, there is a massive effort to discover its structure and decipher its function. Our understanding of the niche is continuously changing with reinterpretation of traditional concepts and apprehension of new insights into the biology of hematopoietic cell homing, seeding, and engraftment. Here we discuss some of the early events in hematopoietic stem cell seeding and engraftment and propose a perspective based on visualization of labeled bone marrow cells in real time in vivo. Primary seeding of hematopoietic cells in the bone marrow niches evolves as a complex and dynamic process; however, it follows discrete topological and chronological patterns. Initial seeding occurs on the endosteal surface of the marrow, which includes heterogeneous niches for primary seeding. Several days after transplantation the endosteal niches become more restrictive, hosting primarily mitotically quiescent cells, and gradual centripetal migration is accompanied by engagement in proliferation and differentiation. The hematopoietic niches evolve as heterogeneous three-dimensional microenvironments that are continuously changing over time.

Original languageEnglish
Pages (from-to)4-16
Number of pages13
JournalStem Cells and Development
Issue number1
StatePublished - Feb 2006
Externally publishedYes


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