TY - JOUR
T1 - The suppressant effects of naloxone on food and water intake in the rat
AU - Frenk, Hanan
AU - Rogers, Gerlinda H.
N1 - Funding Information:
1 This work comprised part of a doctoral dissertation submitted by H.F. to UCLA, November 1977. A preliminary report of some of these findings was presented at the Western Pharmacology Society meeting, January 1978. We are indebted to Dr. John C. Liebeskind for his support and helpful input to all phases of these studies and to Ms. Sheila Roberts for preparing the manuscript. This work was supported by USPHS Grant NS 07628 to John C. Liebeskind.
PY - 1979/5
Y1 - 1979/5
N2 - Systemic administration of naloxone to food- or water-deprived male, Sprague-Dawley rats suppresses food and water intake in a dose-dependent fashion. Administration of as little as .1 mg/kg naloxone significantly reduces water intake. Morphine also reduces water intake in a dose-related manner. Nonetheless, when morphine and naloxone are given together at various doses, a competitive interaction is seen, suggesting that the suppressant effects of these drugs are, in part at least, mediated by the same opiate receptors. High (10 mg/kg) but not low (.1 mg/kg) doses of naloxone induce conditioned taste aversion; thus, sickness may be the cause of the suppressant effects of high, but not low, doses of the drug. These findings are discussed in relation to the hypothesis that endogenous opioid substances mediate drive-reduction reward.
AB - Systemic administration of naloxone to food- or water-deprived male, Sprague-Dawley rats suppresses food and water intake in a dose-dependent fashion. Administration of as little as .1 mg/kg naloxone significantly reduces water intake. Morphine also reduces water intake in a dose-related manner. Nonetheless, when morphine and naloxone are given together at various doses, a competitive interaction is seen, suggesting that the suppressant effects of these drugs are, in part at least, mediated by the same opiate receptors. High (10 mg/kg) but not low (.1 mg/kg) doses of naloxone induce conditioned taste aversion; thus, sickness may be the cause of the suppressant effects of high, but not low, doses of the drug. These findings are discussed in relation to the hypothesis that endogenous opioid substances mediate drive-reduction reward.
UR - https://www.scopus.com/pages/publications/0018581765
U2 - 10.1016/S0163-1047(79)92855-3
DO - 10.1016/S0163-1047(79)92855-3
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0018581765
SN - 0163-1047
VL - 26
SP - 23
EP - 40
JO - Behavioral and Neural Biology
JF - Behavioral and Neural Biology
IS - 1
ER -