The SUMO system in Caenorhabditis elegans development

Limor Broday*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

SUMO, a small ubiquitin-like modifier, is a highly conserved post translational modification and a central regulatory system in eukaryotes. Sumoylation modulates the activities of multiple proteins, mainly in the nucleus, such as transcription factors, chromatin modifiers, and proteins involved in DNA replication and repair. However, SUMO also modifies substrates in the cytoplasm, mitochondria, plasma and ER membrane. This review summarizes our current knowledge on the functions of sumoylation in C. elegans development. SUMO modification is highly reversible and several examples described here establish its function as a molecular switch during embryogenesis and postembryonic organogenesis.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalInternational Journal of Developmental Biology
Volume61
Issue number3-5
DOIs
StatePublished - 2017

Keywords

  • C. elegans
  • Post translational modifications
  • SUMO

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