The study of nevi in children: Principles learned and implications for melanoma diagnosis

Alon Scope, Michael A. Marchetti, Ashfaq A. Marghoob, Stephen W. Dusza, Alan C. Geller, Jaya M. Satagopan, Martin A. Weinstock, Marianne Berwick, Allan C. Halpern*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive understanding of the morphologic characteristics of nevi in different anatomic locations, in association with the patient's age and pigmentary phenotype may aid in the identification of melanomas. When monitoring melanocytic lesions over time, it is essential to differentiate normal from abnormal change. This review summarizes the rapidly expanding body of literature relevant to nevus phenotype, particularly in the context of our experience with the Study of Nevi in Children (SONIC) Project.

Original languageEnglish
Pages (from-to)813-823
Number of pages11
JournalJournal of the American Academy of Dermatology
Volume75
Issue number4
DOIs
StatePublished - 1 Oct 2016

Funding

FundersFunder number
National Institutes of Health
National Cancer InstituteP30CA008748
National Institute of Arthritis and Musculoskeletal and Skin DiseasesR01-AR049342

    Keywords

    • adolescence
    • childhood
    • dermoscopy
    • detection
    • melanoma
    • nevi
    • nevogenesis

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