The structural stability of negative symptoms over time

Noham Wolpe, Emilio Fernandez-Egea*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Negative symptoms remain poorly understood and treated despite their huge impact on patients' lives and clinical outcomes. This is partly because of ongoing debates about the clinical constructs underlying negative symptoms. A longitudinal analysis of the structure of negative symptoms presented in BJPsych Open reports striking temporal stability of symptom structure, which behaves as a few independent domains. This further underscores the need to address specific symptom domains when considering interventions or pathophysiology studies.

Original languageEnglish
Article numbere208
JournalBJPsych Open
Issue number6
StatePublished - 3 Nov 2023


FundersFunder number
Medical Research Council
National Institute for Health and Care ResearchACF-2019-14-013
Israel Science Foundation1603/22
NIHR Cambridge Biomedical Research CentreBRC-1215–20014


    • Negative symptoms
    • longitudinal analysis
    • motivation
    • network analysis
    • psychotic disorders/schizophrenia

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