The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease

R. Fusman; R. Rotstein; D. Zeltser; V. Prochorov; I. Shapira; N. M. Bornstein; G. Keren; A. Roth; H. I. Miller; D. Avitzour; N. Arber; S. Berliner

doi:10.1007/s005920170028

The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease

R. Fusman, R. Rotstein, D. Zeltser, V. Prochorov, I. Shapira, N. M. Bornstein, G. Keren, A. Roth, H. I. Miller, D. Avitzour, N. Arber, S. Berliner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Abstract White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	Acta Diabetologica
Volume	38
Issue number	1
DOIs	https://doi.org/10.1007/s005920170028
State	Published - 2001
Externally published	Yes

Keywords

Diabetes mellitus
Leukocyte adhesiveness/aggregation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s005920170028

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Fusman, R., Rotstein, R., Zeltser, D., Prochorov, V., Shapira, I., Bornstein, N. M., Keren, G., Roth, A., Miller, H. I., Avitzour, D., Arber, N., & Berliner, S. (2001). The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease. Acta Diabetologica, 38(1), 43-49. https://doi.org/10.1007/s005920170028

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abstract = "Abstract White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.",

keywords = "Diabetes mellitus, Leukocyte adhesiveness/aggregation",

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Fusman, R, Rotstein, R, Zeltser, D, Prochorov, V, Shapira, I , Bornstein, NM , Keren, G, Roth, A, Miller, HI, Avitzour, D, Arber, N & Berliner, S 2001, 'The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease', Acta Diabetologica, vol. 38, no. 1, pp. 43-49. https://doi.org/10.1007/s005920170028

TY - JOUR

T1 - The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease

AU - Fusman, R.

AU - Rotstein, R.

AU - Zeltser, D.

AU - Prochorov, V.

AU - Shapira, I.

AU - Bornstein, N. M.

AU - Keren, G.

AU - Roth, A.

AU - Miller, H. I.

AU - Avitzour, D.

AU - Arber, N.

AU - Berliner, S.

PY - 2001

Y1 - 2001

N2 - Abstract White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.

AB - Abstract White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.

KW - Diabetes mellitus

KW - Leukocyte adhesiveness/aggregation

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SN - 0940-5429

VL - 38

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JO - Acta Diabetologica

JF - Acta Diabetologica

IS - 1

ER -

The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease

Abstract

Keywords

UN SDGs

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