The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease

R. Fusman, R. Rotstein, D. Zeltser, V. Prochorov, I. Shapira, N. M. Bornstein, G. Keren, A. Roth, H. I. Miller, D. Avitzour, N. Arber, S. Berliner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Abstract White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalActa Diabetologica
Volume38
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Leukocyte adhesiveness/aggregation

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