The spleen and wound healing

N. Werbin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of splenectomy on wound healing has been studied in standard laparotomy wounds in rats. Significant differences in wound histology, fibroblastic labelling indices, bursting pressure, and IgM levels were found between chronically asplenic rats and controls. Autotransplantation of the spleen conferred some increase to wound strength. Acute asplenic rats have not demonstrated the same changes. It is concluded that the spleen influences wound healing probably through a fibroblastic stimulating mechanism.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalEuropean Surgical Research
Issue number2
StatePublished - 1983
Externally publishedYes


  • Fibroblasts
  • Macrophages
  • Platelets
  • Spleen
  • Splenectomy
  • Splenosis
  • Wound Healing


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