TY - JOUR
T1 - The Sla2p/HIP1/HIP1R family
T2 - Similar structure, similar function in endocytosis?
AU - Gottfried, Irit
AU - Ehrlich, Marcelo
AU - Ashery, Uri
PY - 2010
Y1 - 2010
N2 - HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.
AB - HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.
KW - AP180 N-terminal homology (ANTH)
KW - Endocytosis
KW - HIP1-related (HIP1R)
KW - Huntingtin-interacting protein 1 (HIP1)
KW - Sla2p
KW - Talin-like domain
UR - http://www.scopus.com/inward/record.url?scp=76449118339&partnerID=8YFLogxK
U2 - 10.1042/BST0380187
DO - 10.1042/BST0380187
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C2 - 20074057
AN - SCOPUS:76449118339
SN - 0300-5127
VL - 38
SP - 187
EP - 191
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
IS - 1
ER -