The Sla2p/HIP1/HIP1R family: Similar structure, similar function in endocytosis?

Irit Gottfried, Marcelo Ehrlich, Uri Ashery*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p. All three members of the family have a conserved domain structure, suggesting a common function. Over the past decade, a number of studies have characterized these proteins using a combination of biochemical, imaging, structural and genetic techniques. These studies provide valuable information on binding partners, structure and dynamics of HIP1/HIP1R/Sla2p. In general, all suggest a role in CME (clathrin-mediated endocytosis) for the three proteins, though some differences have emerged. In this mini-review we summarize the current views on the roles of these proteins, while emphasizing the unique attributes of each family member.

Original languageEnglish
Pages (from-to)187-191
Number of pages5
JournalBiochemical Society Transactions
Issue number1
StatePublished - 2010


  • AP180 N-terminal homology (ANTH)
  • Endocytosis
  • HIP1-related (HIP1R)
  • Huntingtin-interacting protein 1 (HIP1)
  • Sla2p
  • Talin-like domain


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