The skeletal endocannabinoid system: Clinical and experimental insights

Bitya Raphael, Yankel Gabet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Recently, there has been a rapidly growing interest in the role of cannabinoids in the regulation of skeletal remodeling and bone mass, addressed in basic, translational and clinical research. Since the first publications in 2005, there are more than 1000 publications addressing the skeletal endocannabinoid system. This review focuses on the roles of the endocannabinoid system in skeletal biology via the cannabinoid receptors CB1, CB2 and others. Endocannabinoids play important roles in bone formation, bone resorption and skeletal growth, and are sometimes age, gender, species and strain dependent. Controversies in the literature and potential therapeutic approaches targeting the endocannabinoid system in skeletal disorders are also discussed.

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number3
StatePublished - 1 May 2016


  • cannabinoid receptors 1 and 2 (CB1, CB2)
  • cannabinoids
  • osteoblasts
  • osteoclasts
  • osteoporosis


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