The significance of soluble interleukin-2, soluble interleukin-2 receptors, soluble ICAM-1 and β2-microglobulin in breast cancer patients

B. Klein; I. Levin; B. Kfir; M. Mishaeli; J. Shapira; T. Klein

doi:10.1159/000217946

The significance of soluble interleukin-2, soluble interleukin-2 receptors, soluble ICAM-1 and β₂-microglobulin in breast cancer patients

B. Klein^*, I. Levin, B. Kfir, M. Mishaeli, J. Shapira, T. Klein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

The serum levels of soluble interleukin-2 (sIL-2), sIL-2 receptors (sIL-2R), β₂-microglobulin (β₂M) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by the ELISA technique in 129 breast cancer patients and 40 controls. The median serum levels of sIL2-R, β₂M and sICAM-1 were significantly higher and sIL-2 significantly lower than controls. sIL-2R, sICAM-1 and β₂M levels were significantly higher in patients with metastatic disease compared to patients on long-term follow-up with no active disease. Initial study measurements of these markers could not identify patients at high risk for relapse. These findings suggest that the sIL-2R level is indicative of metastatic disease and together with other parameters of immune activation may be of help in monitoring disease activity in breast cancer patients.

Original language	English
Pages (from-to)	290-296
Number of pages	7
Journal	Tumor Biology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1159/000217946
State	Published - 1995
Externally published	Yes

Keywords

Breast cancer
Soluble ICAM-1
Soluble IL-2
Soluble IL-2R
ß2-Microglobulin

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000217946

Cite this

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title = "The significance of soluble interleukin-2, soluble interleukin-2 receptors, soluble ICAM-1 and β2-microglobulin in breast cancer patients",

abstract = "The serum levels of soluble interleukin-2 (sIL-2), sIL-2 receptors (sIL-2R), β2-microglobulin (β2M) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by the ELISA technique in 129 breast cancer patients and 40 controls. The median serum levels of sIL2-R, β2M and sICAM-1 were significantly higher and sIL-2 significantly lower than controls. sIL-2R, sICAM-1 and β2M levels were significantly higher in patients with metastatic disease compared to patients on long-term follow-up with no active disease. Initial study measurements of these markers could not identify patients at high risk for relapse. These findings suggest that the sIL-2R level is indicative of metastatic disease and together with other parameters of immune activation may be of help in monitoring disease activity in breast cancer patients.",

keywords = "Breast cancer, Soluble ICAM-1, Soluble IL-2, Soluble IL-2R, {\ss}2-Microglobulin",

author = "B. Klein and I. Levin and B. Kfir and M. Mishaeli and J. Shapira and T. Klein",

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AU - Levin, I.

AU - Kfir, B.

AU - Mishaeli, M.

AU - Shapira, J.

AU - Klein, T.

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N2 - The serum levels of soluble interleukin-2 (sIL-2), sIL-2 receptors (sIL-2R), β2-microglobulin (β2M) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by the ELISA technique in 129 breast cancer patients and 40 controls. The median serum levels of sIL2-R, β2M and sICAM-1 were significantly higher and sIL-2 significantly lower than controls. sIL-2R, sICAM-1 and β2M levels were significantly higher in patients with metastatic disease compared to patients on long-term follow-up with no active disease. Initial study measurements of these markers could not identify patients at high risk for relapse. These findings suggest that the sIL-2R level is indicative of metastatic disease and together with other parameters of immune activation may be of help in monitoring disease activity in breast cancer patients.

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KW - Soluble IL-2R

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