The significance of C3 and C4 complement levels in lupus nephritis

Y. Levo, A. I. Pick

Research output: Contribution to journalArticlepeer-review


C3 and C4 serum complement component levels were examined during various stages of disease activity in 14 SLE patients. It was found that C3 levels were more sensitive index of disease activity than those of C4. C3 levels lower than C4 as expressed by a C3/C4<0.5 were found in 25% of the examined disease episodes; they were only observed in patients with renal involvement during or next to periods of disease activity. We suggest that such a pattern of C3 and C4 when found during the follow-up of SLE patients indicates active renal disease, and implies the recruitment of the alternate pathway for the activation of the complement system.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalInternational Urology and Nephrology
Issue number3-4
StatePublished - Sep 1974


Dive into the research topics of 'The significance of C3 and C4 complement levels in lupus nephritis'. Together they form a unique fingerprint.

Cite this