TY - JOUR
T1 - The significance of a dipyridamole induced 99mTc-MIBI perfusion abnormality on single photon emission tomography
T2 - a quantitative validation with labelled water and positron emission tomography
AU - Rechavia, Eldad
AU - Galassi, Alfredo R.
AU - Araujo, Luis I.
AU - Halson, Peter
AU - Lammertsma, Adriaan A.
AU - Jones, Terry
AU - Lavender, John P.
AU - Maseri, Attilio
PY - 1992/12
Y1 - 1992/12
N2 - To relate technetium-99m 2-methoxy-isobutylisonitrile (99mTc-MIBI) uptake to regional myocardial blood flow (rMBF), 99mTc-MIBI single photon emission tomography (SPET) and H215O positron emission tomography (PET) scans were obtained at rest and after dipyridamole infusion in six patients with single vessel coronary artery disease. 99mTc-MIBI and H215O data sets were created for each segment perfused by the stenotic vessel and for a normal reference area, assigning regions on the SPET tomograms to comparable regions on the PET by similar transaxial image reconstructions. All patients demonstrated post-dipyridamole 99mTc-MIBI perfusion defects in the territories supplied by the stenotic arteries. Resting rMBF in these regions was slightly lower than that in the normal areas (0.82±0.05 vs 0.90±0.09 ml/g/min, P=NS). A 43%±14% reduction in 99mTc-MIBI activity in the area at risk was coupled with on average a 60%±9% reduction in post-dipyridamole rMBF compared with control regions (0.98±0.08 vs 2.52±0.51 ml/g/min, P<0.001). Thus, SPET assessment of 99mTc-MIBI uptake tends to underestimate the perfusion contrast between areas with normal and areas with low coronary vasodilatory reserve when compared to PET. However, these findings may still not affect the clinical usefulness of 99mTc-MIBI and more extensive studies are required to confirm these results in the clinical environment.
AB - To relate technetium-99m 2-methoxy-isobutylisonitrile (99mTc-MIBI) uptake to regional myocardial blood flow (rMBF), 99mTc-MIBI single photon emission tomography (SPET) and H215O positron emission tomography (PET) scans were obtained at rest and after dipyridamole infusion in six patients with single vessel coronary artery disease. 99mTc-MIBI and H215O data sets were created for each segment perfused by the stenotic vessel and for a normal reference area, assigning regions on the SPET tomograms to comparable regions on the PET by similar transaxial image reconstructions. All patients demonstrated post-dipyridamole 99mTc-MIBI perfusion defects in the territories supplied by the stenotic arteries. Resting rMBF in these regions was slightly lower than that in the normal areas (0.82±0.05 vs 0.90±0.09 ml/g/min, P=NS). A 43%±14% reduction in 99mTc-MIBI activity in the area at risk was coupled with on average a 60%±9% reduction in post-dipyridamole rMBF compared with control regions (0.98±0.08 vs 2.52±0.51 ml/g/min, P<0.001). Thus, SPET assessment of 99mTc-MIBI uptake tends to underestimate the perfusion contrast between areas with normal and areas with low coronary vasodilatory reserve when compared to PET. However, these findings may still not affect the clinical usefulness of 99mTc-MIBI and more extensive studies are required to confirm these results in the clinical environment.
KW - Dipyridamole
KW - Positron emission tomography
KW - Single photon emission tomography
KW - Technetium-99m 2-methoxy-isobutyl-isonitrile
UR - http://www.scopus.com/inward/record.url?scp=0026620698&partnerID=8YFLogxK
U2 - 10.1007/BF00180866
DO - 10.1007/BF00180866
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C2 - 1464357
AN - SCOPUS:0026620698
SN - 0340-6997
VL - 19
SP - 1044
EP - 1049
JO - European Journal of Nuclear Medicine
JF - European Journal of Nuclear Medicine
IS - 12
ER -