TY - JOUR
T1 - The signal attenuation rat model of obsessive-compulsive disorder
T2 - A review
AU - Joel, Daphna
PY - 2006/7
Y1 - 2006/7
N2 - During the last 30 years, there have been many attempts to develop animal models of obsessive-compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews a recently developed rat model of OCD, namely, signal attenuation. Results of pharmacological and lesion studies are presented and evaluated with respect to the pharmacology and pathophysiology of OCD. It is argued that signal attenuation is a rat model of OCD with construct (derived from similarity in the underlying mechanisms), predictive (derived from similarity in response to treatment), and face (derived from phenomenological similarity between "compulsive" behavior in the model and compulsions in OCD patients) validity.
AB - During the last 30 years, there have been many attempts to develop animal models of obsessive-compulsive disorder (OCD), in the hope that they may provide a route for furthering our understanding and treatment of this disorder. The present paper reviews a recently developed rat model of OCD, namely, signal attenuation. Results of pharmacological and lesion studies are presented and evaluated with respect to the pharmacology and pathophysiology of OCD. It is argued that signal attenuation is a rat model of OCD with construct (derived from similarity in the underlying mechanisms), predictive (derived from similarity in response to treatment), and face (derived from phenomenological similarity between "compulsive" behavior in the model and compulsions in OCD patients) validity.
KW - Animal model
KW - Compulsive lever-pressing
UR - http://www.scopus.com/inward/record.url?scp=33744962934&partnerID=8YFLogxK
U2 - 10.1007/s00213-006-0387-2
DO - 10.1007/s00213-006-0387-2
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AN - SCOPUS:33744962934
SN - 0033-3158
VL - 186
SP - 487
EP - 503
JO - Psychopharmacology
JF - Psychopharmacology
IS - 4
ER -