The short and the long: Non-coding RNAs and growth factors in cancer progression

Aldema Sas-Chen, Swati Srivastava, Yosef Yarden

Research output: Contribution to journalReview articlepeer-review

Abstract

A relatively well-understood multistep process enables mutation-bearing cells to form primary tumours, which later use the circulation system to colonize new locations and form metastases. However, in which way the emerging abundance of different non-coding RNAs supports tumour progression is poorly understood. Here, we review new lines of evidence linking long and short types of non-coding RNAs to signalling pathways activated in the course of cancer progression by growth factors and by the tumour micro-environment. Resolving the new dimension of non-coding RNAs in oncogenesis will probably translate to earlier detection of cancer and improved therapeutic strategies.

Original languageEnglish
Pages (from-to)51-64
Number of pages14
JournalBiochemical Society Transactions
Volume45
Issue number1
DOIs
StatePublished - 8 Feb 2017
Externally publishedYes

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