The secretion of Duvernoy's gland of Malpolon monspessulanus induces haemorrhage in the lungs of mice

H. I. Rosenberg, S. Kinamon, E. Kochva, A. Bdolah*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A toxic protein that induces death of mice with profuse bleeding from the nostrils was isolated from the secretion of Duvernoy's gland of Malpolon monspessulanus (Colubridae). The toxic protein, referred to as CM-b, showed mainly one band on SDS-PAGE corresponding to a mol. wt of 24,000. Its intravenous ld50 in mice was 1 μg/g and i.v. injections of lethal or sublethal doses induced haemorrhage in the lungs. When injected into the skin of mice, however, the toxin was not haemorrhagic. CM-b showed no proteolytic or procoagulant activity. The nature of this and other components from Duvernoy's secretion of colubrids that cause similar effects remains to be established.

Original languageEnglish
Pages (from-to)920-924
Number of pages5
JournalToxicon
Volume30
Issue number8
DOIs
StatePublished - Aug 1992

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