TY - JOUR
T1 - The search for systemic biomarkers for monitoring degenerative lumbar spinal disorders
AU - Tarabeih, Nader
AU - Shalata, Adel
AU - Higla, Orabi
AU - Kalinkovich, Alexander
AU - Livshits, Gregory
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2022/12
Y1 - 2022/12
N2 - Objectives: In our previous study, we reported that low back pain (LBP) severity and disability significantly correlate with body composition and several blood biochemical factors. Herein, we tested the hypothesis that these covariates are associated with anatomical deformations of the lumbar spine, in particular, radiographic facet joint osteoarthritis (FJOA) and lumbar disc degeneration (LDD) features important contributors to LBP. Methods: CT and MRI images of the lumbar spine were obtained from 200 individuals suffering from LBP-sciatica. We examined the FJOA and total LDD score - the sum of the scores of the three radiographic features (intervertebral disc herniation, osteophythosis and spondylolisthesis) at the L1 - S1 vertebral levels. By implementing a bioelectrical impedance analysis, we assessed the participants for body composition, specifically, extracellular water (ECW). Plasma levels of growth and differentiation factor 15 (GDF-15) and visceral adipose tissue-derived serine protease inhibitor (vaspin), were detected by ELISA. Results: By conducting a series of multivariable regression analyses, we report that the circulating levels of GDF-15, vaspin, and ECW are significantly and independently associated with FJOA scores [βGDF15 = 0.38 ± 0.08, p = 0.0001; βVASPIN = 0.36 ± 0.07, p = 0.000004; βECW = 0.24 ± 0.07, p = 0.002]. The levels of GDF-15 (β = 0.30 ± 0.10, p = 0.007) and ECW (β = 0.20 ± 0.09, p = 0.03) were also found significantly associated with the LDD scores. Conclusion: The obtained new data suggest that GDF-15, vaspin and ECW may serve as biomarkers for FJOA and LDD phenotypes.
AB - Objectives: In our previous study, we reported that low back pain (LBP) severity and disability significantly correlate with body composition and several blood biochemical factors. Herein, we tested the hypothesis that these covariates are associated with anatomical deformations of the lumbar spine, in particular, radiographic facet joint osteoarthritis (FJOA) and lumbar disc degeneration (LDD) features important contributors to LBP. Methods: CT and MRI images of the lumbar spine were obtained from 200 individuals suffering from LBP-sciatica. We examined the FJOA and total LDD score - the sum of the scores of the three radiographic features (intervertebral disc herniation, osteophythosis and spondylolisthesis) at the L1 - S1 vertebral levels. By implementing a bioelectrical impedance analysis, we assessed the participants for body composition, specifically, extracellular water (ECW). Plasma levels of growth and differentiation factor 15 (GDF-15) and visceral adipose tissue-derived serine protease inhibitor (vaspin), were detected by ELISA. Results: By conducting a series of multivariable regression analyses, we report that the circulating levels of GDF-15, vaspin, and ECW are significantly and independently associated with FJOA scores [βGDF15 = 0.38 ± 0.08, p = 0.0001; βVASPIN = 0.36 ± 0.07, p = 0.000004; βECW = 0.24 ± 0.07, p = 0.002]. The levels of GDF-15 (β = 0.30 ± 0.10, p = 0.007) and ECW (β = 0.20 ± 0.09, p = 0.03) were also found significantly associated with the LDD scores. Conclusion: The obtained new data suggest that GDF-15, vaspin and ECW may serve as biomarkers for FJOA and LDD phenotypes.
KW - Body composition
KW - Facet joint osteoarthritis
KW - GDF-15
KW - Low back pain
KW - Lumbar intervertebral disk
KW - Vaspin
UR - http://www.scopus.com/inward/record.url?scp=85162333910&partnerID=8YFLogxK
U2 - 10.1016/j.ocarto.2022.100323
DO - 10.1016/j.ocarto.2022.100323
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C2 - 36601335
AN - SCOPUS:85162333910
SN - 2665-9131
VL - 4
JO - Osteoarthritis and Cartilage Open
JF - Osteoarthritis and Cartilage Open
IS - 4
M1 - 100323
ER -