TY - JOUR
T1 - The search for new triazole antifungal agents
AU - Koltin, Yigal
AU - Hitchcock, Christopher A.
PY - 1997/8
Y1 - 1997/8
N2 - The first generation antifungal agent triazoles, fluconazole and itraconazole, have revolutionised the treatment of serious fungal infections such as mucosal and invasive candidiasis and cryptococcal meningitis. However, the treatment of some fungal infections, particularly aspergillosis, is still far from satisfactory and thus there is an important requirement for new broad-spectrum antifungal agents. The new second generation triazoles voriconazole and SCH-56592 show considerable promise in achieving this goal in the near future.
AB - The first generation antifungal agent triazoles, fluconazole and itraconazole, have revolutionised the treatment of serious fungal infections such as mucosal and invasive candidiasis and cryptococcal meningitis. However, the treatment of some fungal infections, particularly aspergillosis, is still far from satisfactory and thus there is an important requirement for new broad-spectrum antifungal agents. The new second generation triazoles voriconazole and SCH-56592 show considerable promise in achieving this goal in the near future.
UR - http://www.scopus.com/inward/record.url?scp=0031197111&partnerID=8YFLogxK
U2 - 10.1016/S1367-5931(97)80007-5
DO - 10.1016/S1367-5931(97)80007-5
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AN - SCOPUS:0031197111
SN - 1367-5931
VL - 1
SP - 176
EP - 182
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 2
ER -