The role of superoxide dismutation in malaria parasites

Eli Schwartz*, Amram Samuni, Ilanit Friedman, Ernest Hempelmann, Jacob Golenser

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidant stress is associated with the generation of reactive oxygen species that are responsible for the damage of a variety of cellular components. The prevention of such biological damage can be achieved by dismutation of superoxide to H2O2 which in turn is removed by catalase and GSH peroxidase. However, redox-active iron released during the development of plasmodia in the erythrocyte can mediate the conversion of H2O2 to hydroxyl radical which is more reactive. The roles of SOD and the nitroxide SOD mimic 4-OH,2,2,6,6,tetramethyl piperidine-N-oxyl (Tempol) were examined in P. falciparum grown in vitro. Both compounds did not prevent the interference with growth inflicted by various inducers of oxidant stress. Moreover. Tempol inhibited parasite growth, in agreement with previous experiments depicting accelerated mortality in SOD overexpressing mouse model of malaria. Probably, effective defense against ROS requires balanced increments in antioxidant enzymes and is not necessarily improved by an increase in the activity of one enzyme.

Original languageEnglish
Pages (from-to)361-370
Number of pages10
JournalInflammation
Volume23
Issue number4
StatePublished - 1999

Funding

FundersFunder number
Francess WeinsteinFoundation
USA-Israel
United States-Israel Binational Science Foundation95–00287

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