The role of sperm‐bound hyaluronidase in the dispersal of the cumulus oophorus surrounding rat ova

Lawrence M. Lewin*, Zvi Nevo, Amos Gabsu, Ruth Weissenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Only a very small portion (4–7%) of the hyaluronidase of rat sperm obtained from the caput or cauda epididymis was released during incubation in capacitation medium for up to 24 h at 37°C. A portion of the cell‐associated hyaluronidase was accessible to external substrates, allowing sperm suspensions to lyse glycosaminoglycans of cumulus clots rapidly, even without capacitation. This process appears to represent the employment of an enzyme bound to the sperm cell, analogous to the use of solid‐phase enzymes in current enzyme technology.

Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalInternational Journal of Andrology
Volume5
Issue number1
DOIs
StatePublished - Feb 1982

Keywords

  • cumulus
  • egg
  • hyaluronidase
  • oophorus
  • sperm

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