TY - JOUR
T1 - The role of prostaglandins in experimental arthritis in the rat.
AU - Floman, Y.
AU - Okon, E.
AU - Zor, U.
PY - 1977/6
Y1 - 1977/6
N2 - In the experimental model of streptococcal CFE-induced arthritis, PGE and PGF concentrations rise significantly. This is due to an increase both in the substrate concentration and the enzyme activity for PG biosynthesis. Indomethacin therapy inhibited PG synthesis and diminished some of the gross, but not the histological, features of the inflammatory response. These results lend further support to the contention that the beneficial effect of indomethacin in arthritis is due to inhibition of PG biosynthesis.
AB - In the experimental model of streptococcal CFE-induced arthritis, PGE and PGF concentrations rise significantly. This is due to an increase both in the substrate concentration and the enzyme activity for PG biosynthesis. Indomethacin therapy inhibited PG synthesis and diminished some of the gross, but not the histological, features of the inflammatory response. These results lend further support to the contention that the beneficial effect of indomethacin in arthritis is due to inhibition of PG biosynthesis.
UR - http://www.scopus.com/inward/record.url?scp=0017506417&partnerID=8YFLogxK
U2 - 10.1097/00003086-197706000-00036
DO - 10.1097/00003086-197706000-00036
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C2 - 195764
AN - SCOPUS:0017506417
SN - 0009-921X
VL - 125
SP - 214
EP - 220
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
ER -