The Role of Plastics in the Spectrum of Autoimmune Disease-Bisphenol A

Kassem Sharif, Benjamin Lichtbroun, Chen Rizenbah, Yehuda Shoenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Bisphenol A (BPA) is a commonly used substance in epoxy resins and plastics. It has been suggested that under certain environmental factors, BPA can leach out of the products. BPA has been shown to be an endocrine disruptor that binds to estrogen receptors and can influence bodily functions. Recent studies highlighted the influence of BPA exposure to the development and progression of certain autoimmune diseases including MS, T1DM, and thyroid autoimmunity. Autoimmune disease results from the loss of tolerance to self-tissues. The multifactorial etiopathogenesis of autoimmune diseases points toward the pivotal role of genetic, epigenetic, and environmental factors. In this factor, we explore the effect of BPA on certain autoimmune conditions.

Original languageEnglish
Title of host publicationMosaic of Autoimmunity
Subtitle of host publicationThe Novel Factors of Autoimmune Diseases
Number of pages4
ISBN (Electronic)9780128143087
ISBN (Print)9780128143070
StatePublished - 13 Feb 2019


  • Autoimmune diseases
  • Bisphenol A
  • Estrogens
  • Plastics


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