The role of phosphatidylinositol-transfer proteins at membrane contact sites

Michael Selitrennik, Sima Lev*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Phosphatidylinositol-transfer proteins (PITPs) have been initially identified as soluble factors that accelerate the monomeric exchange of either phosphatidylinositol (PI) or phosphatidylcholine (PC) between membrane bilayers in vitro. They are highly conserved in eukaryotes and have been implicated in different cellular processes, including vesicular trafficking, signal transduction, and lipid metabolism. Recent studies suggest that PITPs function at membrane contact sites (MCSs) to facilitate the transport of PI from its synthesis site at the endoplasmic reticulum (ER) to various membrane compartments. In this review, we describe the underlying mechanism of PITPs targeting to MCSs, discuss their cellular roles and potential mode of action.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalBiochemical Society Transactions
Issue number2
StatePublished - 15 Apr 2016
Externally publishedYes


  • Lipid transfer
  • Membrane contact sites
  • PI-transfer proteins
  • Phosphoinositides
  • Signaling


Dive into the research topics of 'The role of phosphatidylinositol-transfer proteins at membrane contact sites'. Together they form a unique fingerprint.

Cite this