The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis*, Ian A. Prior

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • Compartmentalization
  • Nanocluster
  • Palmitoylation
  • Ras
  • Signalling
  • Trafficking

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