The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg; Alex J. Laude; Alison J. Beckett; Craig J. Mageean; Veronica Aran; Maria Hernandez-Valladares; Yoav I. Henis; Ian A. Prior

doi:10.1042/BST20120268

The role of palmitoylation in regulating Ras localization and function

Sharon Eisenberg, Alex J. Laude, Alison J. Beckett, Craig J. Mageean, Veronica Aran, Maria Hernandez-Valladares, Yoav I. Henis^*, Ian A. Prior

^*Corresponding author for this work

Department of Neurobiology

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120268
State	Published - Feb 2013

Keywords

Compartmentalization
Nanocluster
Palmitoylation
Ras
Signalling
Trafficking

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10.1042/BST20120268

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abstract = "Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.",

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AU - Henis, Yoav I.

AU - Prior, Ian A.

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KW - Signalling

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The role of palmitoylation in regulating Ras localization and function

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Keywords

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