TY - JOUR
T1 - The Role of Oncogenic Viruses in the Pathogenesis of Hepatocellular Carcinoma
AU - Zemel, Romy
AU - Issachar, Assaf
AU - Tur-Kaspa, Ran
N1 - Funding Information:
This work was supported in part by the Cesarman Chair for Research in Liver Diseases, Tel Aviv University incumbent, Ran Tur-Kaspa.
PY - 2011/5
Y1 - 2011/5
N2 - HBV and HCV have major roles in hepatocarcinogenesis. More than 500 million people are infected with hepatitis viruses and, therefore, HCC is highly prevalent, especially in those countries endemic for HBV and HCV. Viral and host factors contribute to the development of HCC. The main viral factors include the circulating load of HBV DNA or HCV RNA and specific genotypes. Various mechanisms are involved in the host-viral interactions that lead to HCC development, among which are genetic instability, self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasiveness. Prevention of HBV by vaccination, as well as antiviral therapy against HBV and for HCV seem able to inhibit the development of HCC.
AB - HBV and HCV have major roles in hepatocarcinogenesis. More than 500 million people are infected with hepatitis viruses and, therefore, HCC is highly prevalent, especially in those countries endemic for HBV and HCV. Viral and host factors contribute to the development of HCC. The main viral factors include the circulating load of HBV DNA or HCV RNA and specific genotypes. Various mechanisms are involved in the host-viral interactions that lead to HCC development, among which are genetic instability, self-sufficiency in growth signals, insensitivity to antigrowth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasiveness. Prevention of HBV by vaccination, as well as antiviral therapy against HBV and for HCV seem able to inhibit the development of HCC.
KW - Cirrhosis
KW - Hepatitis b virus (HBV)
KW - Hepatitis c (HCV)
KW - Hepatocellular carcinoma (HCC)
UR - http://www.scopus.com/inward/record.url?scp=79959304448&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2011.03.001
DO - 10.1016/j.cld.2011.03.001
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C2 - 21689612
AN - SCOPUS:79959304448
SN - 1089-3261
VL - 15
SP - 261
EP - 279
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 2
ER -
