The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia: Lessons from knockout mice

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (α2-α10, β2-β4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. The repertoire of nicotinic subunits in autonomic ganglia includes α3, α5, α7, β2 and β4 subunits. In the last 10 years, heterologous expression studies have revealed much about the nature of neuronal nAChRs. However, there is only limited understanding of subunit actions in autonomic system. Functional deletions of subunit by gene knockout in animals could overcome these limitations. We review recent studies on nAChRs on autonomic ganglia for physiological and pharmacological properties and potential locations of the subunits.

Original languageEnglish
Pages (from-to)341-360
Number of pages20
JournalProgress in Neurobiology
Volume68
Issue number5
DOIs
StatePublished - Dec 2002

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