TY - JOUR
T1 - The role of neuronal nicotinic acetylcholine receptor subunits in autonomic ganglia
T2 - Lessons from knockout mice
AU - Wang, Ningshan
AU - Orr-Urtreger, Avi
AU - Korczyn, Amos D.
N1 - Funding Information:
This work was supported by the Sieratzki Chair of Neurology, Tel Aviv University, and the Miriam Turjanski de Gold Foundation.
PY - 2002/12
Y1 - 2002/12
N2 - Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (α2-α10, β2-β4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. The repertoire of nicotinic subunits in autonomic ganglia includes α3, α5, α7, β2 and β4 subunits. In the last 10 years, heterologous expression studies have revealed much about the nature of neuronal nAChRs. However, there is only limited understanding of subunit actions in autonomic system. Functional deletions of subunit by gene knockout in animals could overcome these limitations. We review recent studies on nAChRs on autonomic ganglia for physiological and pharmacological properties and potential locations of the subunits.
AB - Neuronal nicotinic acetylcholine receptors (nAChR), composed of 12 subunits (α2-α10, β2-β4), are expressed in autonomic ganglia, playing a central role in autonomic transmission. The repertoire of nicotinic subunits in autonomic ganglia includes α3, α5, α7, β2 and β4 subunits. In the last 10 years, heterologous expression studies have revealed much about the nature of neuronal nAChRs. However, there is only limited understanding of subunit actions in autonomic system. Functional deletions of subunit by gene knockout in animals could overcome these limitations. We review recent studies on nAChRs on autonomic ganglia for physiological and pharmacological properties and potential locations of the subunits.
UR - http://www.scopus.com/inward/record.url?scp=0036939994&partnerID=8YFLogxK
U2 - 10.1016/S0301-0082(02)00106-5
DO - 10.1016/S0301-0082(02)00106-5
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AN - SCOPUS:0036939994
VL - 68
SP - 341
EP - 360
JO - Progress in Neurobiology
JF - Progress in Neurobiology
SN - 0301-0082
IS - 5
ER -