The Role of Muscular Weakness in Pathogenesis of Osteoporosis in the Elderly

Michal Be'ery*, Amit Gefen

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

Muscular weakness may alter the mechanical stress flow in bones, thereby interrupting the homeostatic conditions for normal bone mass maintenance. In this study, we developed a biomechanical model of a typical planar trabecular lattice at the femoral neck for predicting long-term changes in trabecular thickness and mechanical properties at this site, under muscular weakness. A combination of hip joint loads lower than 20% the normal load and gluteus force outputs lower than 60% the normal force output resulted in osteoporotic bone structure in terms of morphology, strength and stiffness.

Keywords

  • Biomechanical model
  • Femoral neck fracture
  • Finite element analysis
  • Tissue adaptation
  • Trabecular bone remodeling

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