@article{904486a9cfd8405fac96074e17c2af0f,
title = "The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia",
abstract = "Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.",
keywords = "Hippocampal formation, Latent inhibition, Mesolimbic dopamine system, Nucleus accumbens, Schizophrenia",
author = "Gray, {Jeffrey A.} and Joseph, {Michael H.} and Hemsley, {David R.} and Young, {Andrew M.J.} and {Clea Warburton}, E. and Pascale Boulenguez and Grigoryan, {Gregory A.} and Peters, {Scott L.} and Rawlins, {J. N.P.} and Taib, {C. T.} and Yee, {B. K.} and Helen Cassaday and Ina Weiner and Gilad Gal and Oleg Gusak and Daphna Joel and Eran Shadach and Uri Shalev and Ricardo Tarrasch and Joram Feldon",
note = "Funding Information: Researchin the London laboratoryh as been supported by grants from the U.K. Medical Research Council (MRC) (of which M.H.J. is a membeor f the ExternalS cientificS taff),the WellcomeT rust (Grant nos. 036927a nd0 404841a1n dthe Councilf or Tobacco Research(U .S.A.). Researchin the Oxford laboratory has beens upportebdy the MRC Centref or Brain and BehaviourR. esearchin the Tel Aviv Laboratoryh as beens upportebdy the IsraeliM inistryo f Health( Chief Scientist'Osf fice)( I.W. andJ .F.) andt heI sraelA cademy of SciencesB asic ResearchF und (I.W.). Bristol-Myers SquibbP harmaceuticCaol has provideds upporfto r all threel aboratoriesC.o llaboratiobne tweenth e Tel Aviv and Londonl aboratoriehsa sb eena idedb y grantsfr om the Commissioonf the F,u ropeanC ommunitieasn dthe U.K. MRC.",
year = "1995",
month = nov,
doi = "10.1016/0166-4328(95)00154-9",
language = "אנגלית",
volume = "71",
pages = "19--31,IN3",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",
}